Description
An anti-TB agent; activated intracellularly via Ddn metabolism; kills M. tuberculosis by releasing RNS; active against replicating and non-replicating M. tuberculosis; inhibits growth of susceptible and mono- and multi-drug resistant M. tuberculosis clinical isolates (MICs = 0.015-5 µg/ml); decreases luminescence in the lung to in a mouse model of systemic infection with a reporter strain of M. tuberculosis at 100 mg/kg; decreases M. tuberculosis burden in the lung and spleen in an aerosol challenged guinea pig model of TB at 40 mg/kg per day